Regulation of integrin α6A by lactogenic hormones in rat pancreatic β-cells: Implications for the physiological adaptation to pregnancy.

Annette MøldrupMartin Nerup LindbergElisabeth D GalsgaardUlrik HenriksenLouise Torp Dalgaard Jens Høiriis Nielsen

Published in: Acta physiologica (Oxford, England) (2020)

These results show that integrin-α6 in β-cells is upregulated by lactogenic hormones and is required but not sufficient for the expansion of the β-cell mass in pregnancy in the rat, which may have implications for the understanding and treatment of gestational diabetes mellitus.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
pregnancy outcomes
preterm birth
endoplasmic reticulum stress
signaling pathway
cell death
stem cells