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Genetic Modifiers of Cystic Fibrosis Lung Disease Severity: Whole Genome Analysis of 7,840 Patients.

Yi-Hui ZhouPaul J GallinsRhonda G PaceHong DangMelis A AksitElizabeth E BlueKati J BuckinghamJoseph M CollacoAnna V FainoWilliam W GordonKurt N HetrickHua LingWeifang LiuFrankline M OnchiriKymberleigh PagelElizabeth W PughKaren S RaraighMargaret RosenfeldQuan SunJia WenYun LiHarriet CorvolLisa J StrugMichael J BamshadScott M BlackmanGarry R CuttingRonald L GibsonWanda K O'NealFred A WrightMichael R Knowles
Published in: American journal of respiratory and critical care medicine (2023)
This pre-modulator genomic, transcriptomic, and pathway association study of 7,840 pwCF will facilitate mechanistic and post-modulator genetic studies and, development of novel therapeutics for CF lung disease.
Keyphrases
  • cystic fibrosis
  • copy number
  • genome wide
  • pseudomonas aeruginosa
  • lung function
  • small molecule
  • single cell
  • chronic obstructive pulmonary disease
  • case control