Body composition in late midlife as a predictor of accelerated age-associated deficit accumulation from late midlife into old age: a longitudinal birth cohort study.

In late midlife, greater adiposity (%BF) among women and abdominal obesity (WHR) among men may predispose to higher levels of frailty from late midlife into old age. Greater lean mass alone may be protective of frailty, but not in the presence of high fat mass.