The Role of Hematopoietic Cell Transplant in the Glycoprotein Diseases.
Brianna M NaumchikAshish GuptaHeather Flanagan-SteetRichard A SteetSara S CatheyPaul J OrchardTroy C LundPublished in: Cells (2020)
The glycoprotein disorders are a group of lysosomal storage diseases (α-mannosidosis, aspartylglucosaminuria, β-mannosidosis, fucosidosis, galactosialidosis, sialidosis, mucolipidosis II, mucolipidosis III, and Schindler Disease) characterized by specific lysosomal enzyme defects and resultant buildup of undegraded glycoprotein substrates. This buildup causes a multitude of abnormalities in patients including skeletal dysplasia, inflammation, ocular abnormalities, liver and spleen enlargement, myoclonus, ataxia, psychomotor delay, and mild to severe neurodegeneration. Pharmacological treatment options exist through enzyme replacement therapy (ERT) for a few, but therapies for this group of disorders is largely lacking. Hematopoietic cell transplant (HCT) has been explored as a potential therapeutic option for many of these disorders, as HCT introduces functional enzyme-producing cells into the bone marrow and blood along with the engraftment of healthy donor cells in the central nervous system (presumably as brain macrophages or a type of microglial cell). The outcome of HCT varies widely by disease type. We report our institutional experience with HCT as well as a review of the literature to better understand HCT and outcomes for the glycoprotein disorders.
Keyphrases
- cell cycle arrest
- bone marrow
- cell death
- replacement therapy
- induced apoptosis
- single cell
- pi k akt
- cell therapy
- oxidative stress
- newly diagnosed
- stem cells
- mesenchymal stem cells
- ejection fraction
- type diabetes
- prognostic factors
- smoking cessation
- metabolic syndrome
- spinal cord
- resting state
- skeletal muscle
- white matter
- brain injury
- patient reported outcomes
- neuropathic pain
- lps induced
- functional connectivity