Compound heterozygous MTHFR (C677T and A1298C) variants and anterior STEMI: cause or bystander?
Maria Anna BazmpaniHaralambos KarvounisGeorge KassimisPublished in: Future cardiology (2020)
We present the case of a 40-year-old female patient with ST-segment elevation myocardial infarction successfully treated with a primary percutaneous coronary intervention. Thrombophilia testing revealed compound heterozygous MTHFR (C677T and A1298C) variants. We searched the literature for myocardial infarction in the setting of MTHFR polymorphisms and the possible pathophysiologic mechanisms. In young patients presenting with a thrombotic event, screening for thrombophilia could be beneficial for identification of etiology.
Keyphrases
- st segment elevation myocardial infarction
- percutaneous coronary intervention
- st elevation myocardial infarction
- acute myocardial infarction
- coronary artery disease
- acute coronary syndrome
- copy number
- antiplatelet therapy
- early onset
- coronary artery bypass grafting
- systematic review
- atrial fibrillation
- case report
- left ventricular
- heart failure
- middle aged