Clonal Cell Proliferation in Paroxysmal Nocturnal Hemoglobinuria: Evaluation of PIGA Mutations and T-cell Receptor Clonality.
Joonhong ParkMyung-Shin KimYonggoo KimKyungja HanNack-Gyun ChungBin ChoSung-Eun LeeJong Wook LeePublished in: Annals of laboratory medicine (2019)
PIGA mutations were present in approximately 80% of PNH patients. PNH clone size varies according to blood cell lineage, and clonal cells may obtain proliferation potential or gain a survival advantage over normal cells.
Keyphrases
- induced apoptosis
- cell proliferation
- cell cycle arrest
- end stage renal disease
- single cell
- signaling pathway
- ejection fraction
- chronic kidney disease
- newly diagnosed
- blood pressure
- atrial fibrillation
- prognostic factors
- cell cycle
- stem cells
- cell death
- obstructive sleep apnea
- physical activity
- sleep apnea
- depressive symptoms
- climate change
- binding protein
- sleep quality
- free survival