Epigenetic Silencing Affects l-Asparaginase Sensitivity and Predicts Outcome in T-ALL.

Aurore TouzartEtienne LenglinéMehdi LatiriMohamed BelhocineCharlotte SmithXavier ThomasSalvatore SpicugliaDenis PuthierFrançoise PflumioThibaut LeguayCarlos GrauxYves ChalandonFrançoise HuguetStéphane LeprêtreNorbert IfrahHervé DombretElizabeth MacintyreMathilde HunaultNicolas BoisselVahid Asnafi

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

We conclude that ASNS methylation status at diagnosis may allow individual adaptation of l-asparaginase dose.

Keyphrases

dna methylation
genome wide
gene expression