Tetramethylpyrazine contributes to the neuroprotection in a rodent epileptic model of pentylenetetrazole-induced kindling.

Ravi Chandra Sekhara Reddy Danduga Habbeb Banu Shaik Subramanyam Polopalli Phani Kumar Kola Vijaya Kishore Kanakaraju Dinesh Kumar Kandaswamy

Published in: The Journal of pharmacy and pharmacology (2023)

In conclusion, the TMP attenuated the depression behaviour in the PTZ-induced kindled rats, and reduced the oxidative-nitrosative stress, excitotoxicity, neuroinflammation and histological alterations of the brain.

Keyphrases

high glucose
diabetic rats
traumatic brain injury
drug induced
lipopolysaccharide induced
endothelial cells
white matter
oxidative stress
sleep quality
lps induced
inflammatory response
brain injury