Report from the HarmoSter study: impact of calibration on comparability of LC-MS/MS measurement of circulating cortisol, 17OH-progesterone and aldosterone.
Flaminia FanelliMarco CantùAnastasia TemchenkoMarco MezzulloJohanna M LindnerMirko PeitzschJames M HawleyStephen BrucePierre-Alain BinzMariette T AckermansAnnemieke C HeijboerJody Van den OuwelandDaniel KoepplElena NardiFinlay MacKenzieManfred RauhGraeme EisenhoferBrian G KeevilMichael VogeserUberto PagottoPublished in: Clinical chemistry and laboratory medicine (2022)
Intra-laboratory imprecision and performance with EQA materials were variable. Inter-laboratory performance was mostly within specifications. Although residual variability persists, adopting common traceable calibrators and RMP-determined EQA materials is beneficial for standardization of LC-MS/MS steroid measurements.
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