Frequency of Asymptomatic Optic Nerve Enhancement in a Large Retrospective Cohort of Patients With Aquaporin-4+ NMOSD.
Shailee S ShahPearse MorrisMarina BuciucDeena TajfirouzDean M WingerchukBrian G WeinshenkerEric R EggenbergerMarie Di NomeSean J PittockEoin P FlanaganM Tariq BhattiJohn J ChenPublished in: Neurology (2022)
Asymptomatic optic nerve enhancement occurred in 17% of patients with NMOSD predominantly at the site of prior ON attacks and may represent intermittent blood-brain barrier breakdown or subclinical ON. New asymptomatic enhancement was seen only in 2% of patients. Therapeutic clinical trials for NMOSD require blinded relapse adjudication when assessing treatment efficacy, and it is important to recognize that asymptomatic optic nerve enhancement can occur in patients with ON.
Keyphrases
- optic nerve
- blood brain barrier
- optical coherence tomography
- clinical trial
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- high intensity
- study protocol
- combination therapy
- patient reported outcomes
- brain injury
- phase ii
- subarachnoid hemorrhage