Novel Dihydroorotate Dehydrogenase Inhibitors for Treating Acute Myelogenous Leukemia.

Published in: ACS medicinal chemistry letters (2023)

Provided herein are novel dihydroortate dehydrogenase (DHODH) inhibitors, pharmaceutical compositions, use of such compounds in treating acute myelogenous leukemia (AML), and processes for preparing such compounds.

Keyphrases

acute myeloid leukemia
liver failure
respiratory failure
bone marrow
drug induced
aortic dissection
hepatitis b virus
allogeneic hematopoietic stem cell transplantation