Reset of inflammatory priming of joint tissue and reduction of the severity of arthritis flares by bromodomain inhibition.
Jasna FriščićChristiane ReinwaldMartin BöttcherMiranda HoutmanMaximilien EulerXi ChenKellie I WalkerPhilipp KirchnerHonglin ZhuBenjamin WirthDaniela WeidnerRené KrügerVladimir TrajkovicArif B EkiciKerstin KleinDimitrios MougiakakosCaroline OspeltLarissa Valor-MéndezMarkus H HoffmannPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
Inflammatory tissue priming is dependent on transcriptional regulation by BET proteins, which makes them promising therapeutic targets for preventing arthritis flares in previously affected joints.
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