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Refractory Burkitt Lymphoma With False-positive and False-negative Mass Detected on Positron Emission Tomography-Computed Tomography After Chemotherapy.

Haruko ShimaTorataro TakakiJumpei ItoYu IwabuchiAtsuko NakazawaHiroyuki Shimada
Published in: Journal of pediatric hematology/oncology (2023)
A 4-year-old boy with an abdominal mass extending from the spleen to the lower umbilicus was diagnosed with Burkitt lymphoma stage III. Because the fluorodeoxyglucose uptake on positron emission tomography (PET)-computed tomography of the residual splenic tumor remained elevated, splenectomy was performed. The PET-positive area was composed of inflammatory infiltrates, whereas the PET-negative area was composed of a viable tumor surrounded by necrotic or dying tumor cells. The residual tumor may have been false-negative for PET because of its poor proliferative potential. In this case, the comparison of PET-computed tomography and pathologic findings demonstrates the simultaneous presence of a false-positive inflammatory lesion and a false-negative residual tumor.
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