[Peptide imunofan and moxifloxacin combined effects on toxigenic strain Clostridium difficile in vitro.]

Moxifloxacin and imunofan peptide concentrations - dependent Clostridium difficile growth rate was analyzed in vitro. In the course of our study, it was revealed imunofan peptide at concentrations 0.05, 0.25 μg/ml has antimicrobial characteristics against toxigenic C. difficile strain. At the same time, with the peptide and the antibiotic combined interaction, we observed moxifloxacin concentration 0-1.5 MIC stimulates C. difficile growth, regardless of the imunofan concentration. Concentrations of maximum growth inhibition for C. difficile were also established with the combined effects peptide imunofan and antibiotic moxifloxacin - 1.5 μg/ml and 2.5 MIC, respectively.