Liquiritin Alleviates Depression-Like Behavior in CUMS Mice by Inhibiting Oxidative Stress and NLRP3 Inflammasome in Hippocampus.
Chang LiuDai YuanChi ZhangYe TaoYing MengMengli JinWu SongBingmei WangLin WeiPublished in: Evidence-based complementary and alternative medicine : eCAM (2022)
Liquiritin attenuates depression-like behavior of CUMS mice and inhibited cytokines levels triggered by NLRP3 inflammasome, suggesting the antidepressant action is, at least partially, associated with antioxidant stress and inhibition of NLRP3 inflammasome activation.
Keyphrases
- nlrp inflammasome
- oxidative stress
- depressive symptoms
- high fat diet induced
- sleep quality
- major depressive disorder
- dna damage
- signaling pathway
- wild type
- ischemia reperfusion injury
- mouse model
- insulin resistance
- metabolic syndrome
- induced apoptosis
- brain injury
- anti inflammatory
- adipose tissue
- skeletal muscle
- stress induced
- subarachnoid hemorrhage