Claudin-1 as a novel target gene induced in obesity and associated to inflammation, fibrosis, and cell differentiation.
Pablo Fernández-GarcíaSiri D TaxeråsMarjorie Reyes-FariasLorena GonzálezAndrea Soria-GondekSilvia PelliteroJordi TarascóPau MorenoLauro SumoyJacqueline M StephensLindsey G YooMaría GalánAdriana IzquierdoGema Medina-GómezLaura HerreroPatricia CorralesFrancesc VillarroyaRubén CereijoDavid Sanchez-InfantesPublished in: European journal of endocrinology (2024)
These results suggest that CLDN1 is a novel marker induced in obesity and differentially expressed in T lymphocytes infiltrated in human vWAT as compared with sWAT. This protein may have a crucial role in the crosstalk between T lymphocytes and other adipose tissue cells and may contribute to inflammation, fibrosis, and alter homeostasis and promote metabolic disease in obesity.
Keyphrases
- insulin resistance
- metabolic syndrome
- adipose tissue
- weight loss
- oxidative stress
- high fat diet induced
- type diabetes
- diabetic rats
- high glucose
- weight gain
- endothelial cells
- induced apoptosis
- skeletal muscle
- drug induced
- cell cycle arrest
- copy number
- cell death
- signaling pathway
- genome wide
- liver fibrosis
- gene expression
- binding protein