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Claudin-1 as a novel target gene induced in obesity and associated to inflammation, fibrosis, and cell differentiation.

Pablo Fernández-GarcíaSiri D TaxeråsMarjorie Reyes-FariasLorena GonzálezAndrea Soria-GondekSilvia PelliteroJordi TarascóPau MorenoLauro SumoyJacqueline M StephensLindsey G YooMaría GalánAdriana IzquierdoGema Medina-GómezLaura HerreroPatricia CorralesFrancesc VillarroyaRubén CereijoDavid Sanchez-Infantes
Published in: European journal of endocrinology (2024)
These results suggest that CLDN1 is a novel marker induced in obesity and differentially expressed in T lymphocytes infiltrated in human vWAT as compared with sWAT. This protein may have a crucial role in the crosstalk between T lymphocytes and other adipose tissue cells and may contribute to inflammation, fibrosis, and alter homeostasis and promote metabolic disease in obesity.
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