A feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis.

Wei FanShuhao ZengXiaotang WangGuoqing WangDan LiaoRuonan LiSiyuan HeWanqian LiJiaxing HuangXingran LiJiangyi LiuNa LiShengping Hou

Published in: Genome biology (2024)

Collectively, our study illustrates that H3K9la is important for VEGF-induced angiogenesis, and interruption of the H3K9la/HDAC2 feedback loop may represent a novel therapeutic method for treating pathological neovascularization.

Keyphrases

endothelial cells
high glucose
vascular endothelial growth factor
diabetic rats
transcription factor
histone deacetylase
diabetic retinopathy