Manganese/bipyridine-catalyzed non-directed C(sp3)-H bromination using NBS and TMSN3.

A Mn(II)/bipyridine-catalyzed bromination reaction of unactivated aliphatic C(sp3)-H bonds has been developed using N-bromosuccinimide (NBS) as the brominating reagent. The reaction proceeded in moderate-to-good yield, even on a gram scale. The introduced bromine atom can be converted into fluorine and allyl groups.