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Cannabidiol Alleviates Oral Mucositis by Inhibiting PI3K/Akt/NF-κB-Mediated Pyroptosis.
Jialin Yang
Na Lin
Shuang Li
Zhanhai Dong
Deli Wang
Yong Liu
Yang Zhou
Hui Yuan
Published in:
Balkan medical journal (2024)
Our findings suggest a novel mechanism for controlling OM, in which CBD suppresses the PI3K/Akt/NF-κB signaling pathway and pyroptosis, thereby mitigating OM symptoms.
Keyphrases
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signaling pathway
pi k akt
nlrp inflammasome
cell cycle arrest
induced apoptosis
epithelial mesenchymal transition
radiation induced
cell proliferation
mouse model
radiation therapy
physical activity