Relationship between plasma NFL and disease progression in Parkinson's disease: a prospective cohort study.

Ruwei OuKuncheng LiuJunyu LinTianmi YangYi XiaoQianqian WeiYanbing HouChunyu LiLingyu ZhangZheng JiangBi ZhaoXueping ChenWei SongYing WuHui Fang Shang

Published in: Journal of neurology (2023)

Plasma NFL exhibits a tendency to increase with disease progression, and elevated baseline plasma NFL can serve as a predictor for accelerated motor deterioration and cognitive decline in PD. However, plasma NFL does not have high accuracy to distinguish individuals with early-stage PD from HC.

Keyphrases

cognitive decline
early stage
mild cognitive impairment
squamous cell carcinoma
rectal cancer