Photo-induced mitochondrial DNA damage and NADH depletion by -NO2 modified Ru(II) complexes.

Shuang QiZhihui JinYao JianYuanjun HouChao LiYao Zhao Xuesong Wang Qian-Xiong Zhou

Published in: Chemical communications (Cambridge, England) (2021)

Two mitochondria-localized Ru(ii) complexes with photo-labile ligands were reported to exert one- and two-photon activatable anticancer activity through a dual-function mechanism, i.e. mitochondrial DNA covalent binding after photo-induced ligand dissociation and photo-catalyzed NADH depletion, thus displaying good activity towards cisplatin-resistant cancer cells under both normoxic and hypoxic conditions.

Keyphrases

mitochondrial dna
dna damage
electron transfer
oxidative stress
diabetic rats
high glucose
copy number
drug induced
dna repair
room temperature
dna binding
monte carlo