Pre-diagnosis insulin-like growth factor-I and risk of epithelial invasive ovarian cancer by histological subtypes: A collaborative re-analysis from the Ovarian Cancer Cohort Consortium.

Jennifer OseHelena SchockElizabeth M PooleMatti LehtinenKala VisvanathanKathy HelzlsouerJulie E BuringI-Min LeeAnne TjønnelandMarie-Christine Boutron-RuaultAntonia TrichopoulouAmalia MattielloN Charlotte Onland-MoretElisabete WeiderpassMaría-José SánchezAnnika IdahlRuth C TravisSabina RinaldiMelissa A MerrittNicolas WentzensenShelley S TworogerRudolf KaaksRenée Turzanski Fortner

Published in: Cancer causes & control : CCC (2017)

These results suggest that IGF-I concentrations are inversely associated with EOC risk, independent of histological phenotype. Future prospective research should consider potential mechanisms for this association, including, considering other members of the IGF-family to better characterize the role of IGF-signaling in the etiology of EOC.

Keyphrases

growth hormone
pi k akt
binding protein
quality improvement
current status
signaling pathway
cell proliferation
climate change