PAQR8 promotes breast cancer recurrence and confers resistance to multiple therapies.
Saisai ChenMatt R PaulChristopher J SternerGeorge K BelkaDezhen WangPeining XuAmulya SreekumarTien-Chi PanDhruv K PantIgor MakhlinAngela DeMicheleClementina MesarosLewis A ChodoshPublished in: Breast cancer research : BCR (2023)
Our data provide in vivo evidence that PAQR8 plays a functional role in cancer, implicate PAQR8, cAMP, and ceramide metabolism in breast cancer recurrence, and identify a novel mechanism that may commonly contribute to the acquisition of treatment resistance in breast cancer patients.