Anti-TGF-β/PD-L1 bispecific antibody promotes T cell infiltration and exhibits enhanced antitumor activity in triple-negative breast cancer.
Ming YiYuze WuMengke NiuShuangli ZhuJing ZhangYongxiang YanPengfei ZhouZhijun DaiKongming WuPublished in: Journal for immunotherapy of cancer (2022)
BiTP retains parent antibodies' binding affinity and bioactivity, with superior antitumor activity to parent antibodies in TNBC. Our data suggest that BiTP might be a promising agent for TNBC treatment.