Multivariate Analysis of MRI Biomarkers for Predicting Neurologic Impairment in Cervical Spinal Cord Injury.
J HaefeliMarc C MabrayW D WhetstoneS S DhallJonathan Z PanPavan S UpadhyayulaGeoffrey T ManleyJ C BresnahanMichael S BeattieAdam R FergusonJason F TalbottPublished in: AJNR. American journal of neuroradiology (2016)
This study demonstrates the utility of applying nonlinear principal component analysis for defining the relationship between MR imaging biomarkers in a complex clinical syndrome of cervical spinal cord injury. Of the assessed imaging biomarkers, the intrinsic measures of cord signal abnormality were most predictive of neurologic impairment in acute spinal cord injury, highlighting the value of axial T2 MR imaging.