Two new cycloartane type triterpenes from Dysoxyllum binectariferum .

Dysoxyllum binectariferum is an important medicinal plant known for various biological activities like anti-inflammatory, CNS depressants, contraceptive, analgesic, immunomodulatory, antimalarial, antifeedant, leishmanicidal and antiviral. It is a rich source of rohitukine, a basic skeleton of flavopiridol. Phytochemical investigation of chloroform extracts of Dysoxyllum binectariferum leaves, lead to the isolation of beddomeilactone ( 1 ) and two new cycloartane type triterpenoids beddomeilactol ( 2 ) and binectarilactone-A (3 ) with modified A ring. Compounds were assessed for their in-vitro α- glucosidase inhibitory activity. Compound 1 was found to be most potent, showing IC 50 of 17.99 ± 0.26 µg/ml which is comparable to the positive control acarbose.