Cancer risk in individuals with major birth defects: large Nordic population based case-control study among children, adolescents, and adults.

Dagrun Slettebø DaltveitKari KlungsøyrAnders EngelandAnders EkbomMika GisslerIngrid GlimeliusTom GrotmolLaura Madanat-HarjuojaAnne Gulbech OrdingSolbjørg Makalani Myrtveit SætherHenrik Toft SørensenRebecca TroisiTone Bjørge

Published in: BMJ (Clinical research ed.) (2020)

The increased risk of cancer in individuals with birth defects persisted into adulthood, both for non-chromosomal and chromosomal anomalies. Further studies on the molecular mechanisms involved are warranted.

Keyphrases

young adults
gestational age
papillary thyroid
copy number
physical activity
childhood cancer
squamous cell
pregnancy outcomes
gene expression
case control
dna methylation