Mechanisms underlying remediation of depression-associated anxiety by chronic N-acetyl cysteine treatment.

Suwarna Chakraborty Sunil Jamuna Tripathi Trichur R Raju Byrathnahalli S Shankaranarayana Rao

Published in: Psychopharmacology (2020)

We suggest that beneficial effects of NAC on antidepressive- and antianxiety-like behaviors are at least in part mediated via restoration of amygdalar and HPA axis functioning. Our results support the hypothesis that NAC might be evolved as a therapeutic strategy for reversal of amygdalar dysfunction in depression.

Keyphrases

sleep quality
transcription factor
depressive symptoms
oxidative stress
physical activity
fluorescent probe