Ultrastructural evaluation of urine alkalinization versus hydration on colistin-induced nephrotoxicity.
Berfu KorucuI UnalM PekcanA C InkayaH YeterM A CetinkayaF F KaymazS UnalM AkovaY ErdemPublished in: Human & experimental toxicology (2019)
Colistin was highly nephrotoxic without protection. Light microscopy findings revealed that urinary alkalinization and NaCl hydration were similarly protective. Urine alkalinization further prevents ultrastructural changes as revealed by electron microscopy.
Keyphrases
- electron microscopy
- escherichia coli
- acinetobacter baumannii
- pseudomonas aeruginosa
- klebsiella pneumoniae
- gram negative
- multidrug resistant
- drug resistant
- drug induced
- high glucose
- diabetic rats
- high resolution
- single molecule
- high throughput
- high speed
- cystic fibrosis
- single cell
- mouse model
- label free
- oxidative stress