Telomerase enzyme deficiency promotes metabolic dysfunction in murine hepatocytes upon dietary stress.

Raquel M Alves-PaivaSachiko KajigayaXingmin FengJichun ChenMarie DesiertoSusan WongDanielle M TownsleyFlávia S DonairesAdeline BertolaBin GaoNeal S YoungRodrigo do Tocantins Calado

Published in: Liver international : official journal of the International Association for the Study of the Liver (2017)

Our findings indicate that in telomeropathies short telomeres are not the only molecular trigger and telomerase enzyme deficiency provokes hepatocyte metabolic dysfunction, abrogates response to environmental challenge, and causes cellular injury and steatosis, providing a mechanism for liver damage in telomere diseases.

Keyphrases

oxidative stress
liver injury
insulin resistance
replacement therapy
high fat diet
drug induced
type diabetes
human health
risk assessment
adipose tissue
stress induced
high fat diet induced
life cycle