The transcriptional factor Pbx1 adjusts peripheral B cell homeostasis to constrain lupus autoimmunity.

Shuangshuang GuJinsong ZhangXiaxia HanHuihua DingChao YaoZhizhong YeZhihua YinGuojun HouYang JiangJie QianHaibo ZhouQiang GuoSheng ChenDai DaiNan Shen

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)

Our study reveals the regulatory function and mechanism of Pbx1 in adjusting B-cell homeostasis, and highlights Pbx1 as a therapeutic target in SLE. This article is protected by copyright. All rights reserved.

Keyphrases

systemic lupus erythematosus
disease activity
transcription factor
gene expression
heat shock
chemotherapy induced
heat stress