Targeting GBM with an Oncolytic Picornavirus SVV-001 alone and in combination with fractionated Radiation in a Novel Panel of Orthotopic PDX models.
Huiyuan ZhangYuchen DuLin QiSophie XiaoFrank K BraunMari KogisoYulun HuangFrank HuangAalaa AbdallahMilagros SuarezSekar KarthickNabil M AhmedVita S SalsmanPatricia A BaxterJack M SuDaniel J BratPaul L HellenbeckWan-Yee TeoAkash J PatelXiao-Nan LiPublished in: Journal of translational medicine (2023)
A panel of 17 clinically relevant and molecularly annotated PDOX modes of GBM is developed, and SVV-001 exhibited strong anti-tumor activities in vitro and in vivo.