Cetuximab Exhibits Sex Differences in Lymphatic Exposure after Intravenous Administration in Rats in the Absence of Differences in Plasma Exposure.

Esther KuilamuChristopher SubasicGary J CowinFiona SimpsonRodney F MinchinLisa M Kaminskas

Published in: Pharmaceutical research (2020)

These data suggested that mAbs more efficiently access lymph in females, but this does not affect plasma pharmacokinetics or biodistribution. Further, the data suggest that sex differences observed in humans could be a function of antigen density.

Keyphrases

electronic health record
big data
lymph node
high dose
low dose
pet imaging
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