Contraceptives as possible risk factors for postpartum depression: A retrospective study of the food and drug administration adverse event reporting system, 2004-2015.

Megumi HoribeYuuki HaneJunko AbeToshinobu MatsuiYamato KatoNatsumi UedaSayaka SasaokaYumi MotookaHaruna HatahiraShiori HasegawaYasutomi KinosadaHideaki HaraMitsuhiro Nakamura

Published in: Nursing open (2018)

The reporting odds ratios (95% confidence intervals, CI) of levonorgestrel (an intrauterine device with progestogen), etonogestrel (a hormonal contraceptive implant), sertraline and drospirenone (an oral contraceptive) were 12.5 (8.7-18.0), 14.0 (8.5-22.8), 12.2 (6.5-23.1) and 5.4 (2.7-10.9) respectively. Among the drugs in the US Food and Drug Administration Adverse Event Reporting System database, the use of contraceptives or an intrauterine device with progestogen might convey risk for postpartum depression.

Keyphrases

drug administration
adverse drug
depressive symptoms
electronic health record
sleep quality
emergency department
drug induced
human health
type diabetes
metabolic syndrome
adipose tissue