Kawasaki Disease Associated with SARS-CoV2 in a Pair of Triplets.

Luisa Berenise Gamez-GonzalezLuis Xochihua-DíazMoises Ramirez-LopezMarcela Colmenero-RasconEmiy Yokoyama-RebollarItzya Hernández-SantiagoAbner Bojalil-CabildoMarco Antonio Yamazaki-Nakashimada

Published in: Pediatric allergy, immunology, and pulmonology (2023)

The etiology of Kawasaki disease (KD) and its precise genetic basics remain unknown. Genetic variants affecting immunity have been found in some patients. The occurrence of KD in siblings is rare, but KD pedigrees with multiple affected members have been described in Japan and North America. Cases in twins have been documented. We report 2 pairs of trizygotic triplets who developed KD associated with SARS-CoV2 infection from 2 different families. Our cases show that KD is multifactorial in origin, and both infectious etiology (particularly SARS-CoV2 as in our cases) and genetic factors are relevant in the disease.

Keyphrases

sars cov
respiratory syndrome coronavirus
end stage renal disease
genome wide
ejection fraction
chronic kidney disease
newly diagnosed
risk assessment
copy number
patient reported outcomes
patient reported