Sulforaphane administration alleviates diffuse axonal injury (DAI) via regulation signaling pathway of NRF2 and HO-1.
Dong-Mei WuZi-Hui ZhengShao-Hua FanZi-Feng ZhangGui-Quan ChenJun LuPublished in: Journal of cellular biochemistry (2019)
By activating the Nrf2/HO-1 signaling pathway and reducing the activity of caspase-3, SFN reduces the apoptosis of neurons in brain trauma-induced DAI.
Keyphrases
- signaling pathway
- pi k akt
- cell cycle arrest
- oxidative stress
- induced apoptosis
- diabetic rats
- cell death
- epithelial mesenchymal transition
- endoplasmic reticulum stress
- spinal cord injury
- high glucose
- cell proliferation
- resting state
- spinal cord
- low grade
- functional connectivity
- endothelial cells
- blood brain barrier
- trauma patients
- brain injury
- cerebral ischemia
- high grade