Prospective validation of a model-informed precision dosing tool for vancomycin in intensive care patients.

Rob Ter HeineRon J KeizerKrista van SteegElise J SmoldersMatthijs van LuinHieronymus J DerijksCornelis P C de JagerTim FrenzelRoger J M Brüggemann

Published in: British journal of clinical pharmacology (2020)

Using a systematic approach, with a retrospective evaluation and prospective verification we showed the suitability of a model to predict vancomycin pharmacokinetics for purposes of model-informed precision dosing in clinical practice. The presented methodology may serve a generic approach for evaluation of pharmacometric models for the use of model-informed precision dosing in the clinic.

Keyphrases

clinical practice
end stage renal disease
primary care
ejection fraction
newly diagnosed
peritoneal dialysis
methicillin resistant staphylococcus aureus
patient reported outcomes