Autoantibodies Against Dihydrolipoamide S-Acetyltransferase in Immune-Mediated Neuropathies.

Yuki FukamiMasahiro IijimaHaruki H KoikeSatoru YagiSoma FurukawaNaohiro MouriJun OuchidaAyuka MurakamiMadoka IidaSatoshi YokoiAtsushi HashizumeYohei IguchiShiro ImagamaMasahisa Katsuno

Published in: Neurology(R) neuroimmunology & neuroinflammation (2024)

Reactivity to DLAT was confirmed in patient sera, mainly in patients with CIDP. DLAT is highly expressed in the dorsal root ganglion cells, and anti-DLAT antibody may serve as a biomarker for sensory-dominant neuropathies.

Keyphrases

neuropathic pain
induced apoptosis
cell cycle arrest
spinal cord
case report
systemic lupus erythematosus
endoplasmic reticulum stress
oxidative stress
signaling pathway
cell proliferation
optic nerve