Login / Signup

Use of IV immunoglobulin to treat steroid resistant, immune checkpoint inhibitor-induced pure red cell aplasia: A case report.

Sam Sherratt-MayhewPhillip Lindsay Ross Nicolson
Published in: EJHaem (2024)
Pure red cell aplasia (PRCA) is characterised by normocytic normochromic anaemia, reticulocytopenia and reduced erythroid precursors in bone marrow. PRCA as an immune-related adverse event secondary to immune checkpoint inhibitor (ICI) therapy is rare. Steroids are usually used first line to treat ICI-induced PRCA. Here, we report a case of ICI-induced PRCA with no response to steroids but where intravenous (IV) immunoglobulin was successfully used second line. ICI therapy was reinitiated following PRCA resolution. PRCA recurrence did not occur.
Keyphrases
  • high glucose
  • bone marrow
  • diabetic rats
  • drug induced
  • single cell
  • stem cells
  • mesenchymal stem cells
  • oxidative stress
  • emergency department
  • endothelial cells
  • high dose
  • low dose
  • replacement therapy
  • free survival