p53 immunohistochemistry in high-grade urothelial carcinoma of the bladder is prognostically significant.
Anjelica J HodgsonRonald A GhosseinMichelle R DownesPublished in: Histopathology (2017)
Prior to this study, the p53 null phenotype was not well described in urothelial carcinoma of the bladder. Abnormal p53 immunoexpression (null staining pattern or staining in >50% of cells) is prognostic in terms of oncological outcome.