HIF-1α-activated TMEM237 promotes hepatocellular carcinoma progression via the NPHP1/Pyk2/ERK pathway.
Tianxiang ChenLiang WangChao ChenRuntian LiNing ZhuRunkun LiuYongshen NiuZhengtao XiaoHui LiuQingguang LiuKangsheng TuPublished in: Cellular and molecular life sciences : CMLS (2023)
Our study demonstrated that HIF-1α-activated TMEM237 interacted with NPHP1 to activate the Pyk2/ERK pathway, thereby promoting HCC progression.