Exploratory Study of MYD88 L265P, Rare NLRP3 Variants, and Clonal Hematopoiesis Prevalence in Patients With Schnitzler Syndrome.

Shelly PathakDorota M RowczenioRoger G OwenGina M DoodyDarren J NewtonClaire TaylorJan TaylorCatherine CargoPhilip N HawkinsKaroline KrauseHelen J LachmannSinisa Savic

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2019)

A shared molecular mechanism accounting for the pathogenesis of inflammation in SchS remains elusive. Clonal hematopoiesis is not associated with other somatic mutations found in individuals with SchS or aCAPS.

Keyphrases

copy number
oxidative stress
risk factors
dna methylation