Steroid-tacrolimus drug-drug interaction and the effect of CYP3A genotypes.

Abdelrahman Saqr Mahmoud Al-Kofahi Moataz Ehab Mohamed Casey R Dorr Rory P Remmel Guillaume C Onyeaghala William S Oetting Weihua Guan Kymberly D Watt Arthur J Matas Ajay K Israni Pamala A Jacobson

Published in: British journal of clinical pharmacology (2024)

Steroids increase the clearance of tacrolimus but vary slightly by CYP3A genotype. This is important in individuals of African ancestry who are more likely to carry no LOF alleles, may more commonly receive steroid treatment, and will need higher tacrolimus doses.

Keyphrases

adverse drug
drug induced