Sex-specific genetic architecture of late-life memory performance.
Jaclyn M EissmanDerek B ArcherShubhabrata MukherjeeMichael L LeeSeo-Eun ChoiPhoebe ScollardEmily H TrittschuhJesse B MezWilliam S BushBrian W KunkleAdam C NajKatherine A Giffordnull nullMichael L CuccaroCarlos CruchagaMargaret A Pericak-VanceLindsay A FarrerLi-San WangGerard D SchellenbergRichard P MayeuxJonathan L HainesAngela L JeffersonWalter A KukullC Dirk KeeneAndrew J SaykinPaul M ThompsonEden R MartinDavid A BennettLisa L BarnesJulie A SchneiderPaul K CraneTimothy J HohmanLogan DumitrescuPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
Demonstrated the heritable component of late-life memory is similar across sexes. Identified two genetic loci with a sex-interaction with baseline memory. Identified an X-chromosome locus associated with memory decline in females. Highlighted sex-specific candidate genes and pathways associated with memory. Revealed sex-specific shared genetic architecture between memory and complex traits.