Salicylic Acid-Based Polymeric Contrast Agents for Molecular Magnetic Resonance Imaging of Prostate Cancer.
Sangeeta Ray BanerjeeXiaolei SongXing YangIl MinnAla LisokYanrong ChenAlbert BuiSamit ChatterjeeJian ChenPeter C M van ZijlMichael T McMahonMartin G PomperPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2018)
Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) is an innovative molecular imaging technique in which contrast agents are labeled by saturating their exchangeable proton spins by radio-frequency irradiation. Salicylic acid and its analogues are a promising class of highly sensitive, diamagnetic CEST agents. Herein, polymeric agents grafted with salicylic acid moieties and a known high-affinity ligand targeting prostate-specific membrane antigen in approximately 10:1 molar ratio were synthesized to provide sufficient MRI sensitivity and receptor specificity. The proton-exchange properties of the contrast agent in solution and in an experimental murine model are reported to demonstrate the feasibility of receptor-targeted CEST MRI of prostate cancer. Furthermore, the CEST imaging data were validated with an 111 In-labeled analogue of the agent by in vivo single photon emission computed tomographic imaging and tissue biodistribution studies.
Keyphrases
- contrast enhanced
- magnetic resonance imaging
- prostate cancer
- magnetic resonance
- cancer therapy
- computed tomography
- diffusion weighted imaging
- radical prostatectomy
- high resolution
- drug delivery
- pet imaging
- drug release
- big data
- electronic health record
- mass spectrometry
- radiation therapy
- molecular docking
- living cells
- positron emission tomography
- fluorescence imaging
- data analysis
- artificial intelligence
- molecular dynamics simulations
- photodynamic therapy
- electron transfer