Nitric Oxide modulates spontaneous Ca 2+ release and ventricular arrhythmias during β-adrenergic signalling through S -nitrosylation of Calcium/Calmodulin dependent kinase II.
Amelia S PowerEsther AsamudoLuke P I WorthingtonChidera C AlimRaquel ParackalRachel S WallaceObialunanma V EbenebeJoan Heller BrownMark J KohrDonald M BersJeffrey R EricksonPublished in: bioRxiv : the preprint server for biology (2023)
-nitrosylation at Cys-290 might worsen or sustain β-AR-induced arrhythmias. This has important implications for the administration of NO donors in the clinical setting.