A Pre-Leukemic DNA Methylation Signature in Healthy Individuals at Higher Risk for Developing Myeloid Malignancy.

Zhentang Lao Ling-Wen Ding Qiao-Yang Sun Li Jia Benedict Yan Alvin Yu-Jin Ng Sharah Mae Capinpin Renwei Wang Ying Li Wee-Joo Chng H Phillip Koeffler Woon-Puay Koh Woon Puay Koh Henry Yang Yeow Tee Goh Nicholas Francis Grigoropoulos

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

The epigenetic changes may be acquired independently and prior to somatic mutations that relevant for AML/MDS development. The association between methylation changes and the risk of pre-AML/MDS in these individuals was considerably stronger than somatic mutations, suggesting that methylation changes could be used as biomarkers for pre- AML/MDS screening.

Keyphrases

acute myeloid leukemia
dna methylation
genome wide
copy number
gene expression
allogeneic hematopoietic stem cell transplantation
bone marrow
acute lymphoblastic leukemia
immune response