Downregulation of Kcnq1ot1 attenuates β-cell proliferation and insulin secretion via the miR-15b-5p/Ccnd1 and Ccnd2 axis.

Yanli LiYalan ChenZiyu LiuBeisi LinXiaoyi DengQiwen XiaoZhishan ChenHuiyu YeDanrui ChenYanna SuWangen LiWen Xu

Published in: Acta diabetologica (2022)

Kcnq1ot1 regulated β-cell proliferation and insulin secretion via the miR-15b-5p/Ccnd1 and Ccnd2 axis, which is worthy of further investigation considering its potential in diabetes treatment.

Keyphrases

cell proliferation
cell cycle
type diabetes
cardiovascular disease
pi k akt
signaling pathway
glycemic control
metabolic syndrome
combination therapy
weight loss
replacement therapy