Vitamin D status and latitude predict brain lesions in adrenoleukodystrophy.
Keith P Van HarenJacob WilkesAnn B MoserGerald V RaymondTroy RichardsonPatrick AubourgTimothy W CollinsEllen M MowryJoshua L BonkowskyPublished in: Annals of the Child Neurology Society (2023)
Using independent cohorts, we found that ALD boys with lower pre-morbid plasma levels of 25-hydroxyvitamin D, or more northerly latitude of residence, were more likely to develop cALD. These findings offer complementary lines of evidence that vitamin D and/or ultraviolet light exposure influence cALD risk.