Effect of nicastrin on hepatocellular carcinoma proliferation and apoptosis through PI3K/AKT signalling pathway modulation.

Xicheng WangXining WangYunxiuxiu XuMaolin YanWenxin LiJie ChenTao Chen

Published in: Cancer cell international (2020)

We suggest that NCSTN serves as an oncogene in HCC by promoting growth and inhibiting apoptosis via the PI3K/Akt pathway, providing a potential novel therapeutic target for HCC treatment.

Keyphrases

cell cycle arrest
pi k akt
signaling pathway
cell death
endoplasmic reticulum stress
oxidative stress
cell proliferation
risk assessment
human health
climate change
smoking cessation